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In the bacterial KcsA and inwardly rectifying K+ (Kir) channels, glutamic acid is also involved in the action of the selectivity filter.88 Here, the network of residues stabilizing the pore of KcsA involves a Glu71-Asp80 carboxyl-carboxylate interaction behind the selectivity filter, whereas the structure of the pore in Kir channels is stabilized by a Glu-Arg salt bridge.88 Therefore, although Glu is quite conserved among both types of channels, the network of interactions is not translatable from one channel to the other. This clearly shows that different potassium channels are characterized by diverse gating patterns.88

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